正常人尿液中新型中链酰基肉碱的鉴定。
Identification of new medium-chain acylcarnitines present in normal human urine.
作者信息
Libert R, Van Hoof F, Thillaye M, Vincent M F, Nassogne M C, Stroobant V, de Hoffmann E, Schanck A
机构信息
Département de Biologie Clinique, Cliniques Universitaires St. Luc, 10 Avenue Hippocrate, Brussels, B-1200, Belgium.
出版信息
Anal Biochem. 1997 Sep 5;251(2):196-205. doi: 10.1006/abio.1997.2274.
Analysis of urinary medium-chain acylcarnitines extracted on C18 cartridges and gas chromatography mass spectrometry of their fatty acid moieties as picolinyl esters allowed the determination of the chemical structure of previously unidentified acylcarnitines in normal human urine. These are the 2,6-dimethylheptanoyl-, the 2,6-dimethyl-5-heptenoyl-, and the trans- and cis-3,4-methylene heptanoylcarnitines, also named 3-cyclopropane octanoylcarnitines. Assessment of the structure of these cyclopropane derivatives was obtained by 1H and 13C nuclear magnetic resonance spectroscopy. In addition, other acylcarnitines were tentatively identified.
对在C18柱上萃取的尿中中链酰基肉碱及其脂肪酸部分作为吡啶基酯进行气相色谱-质谱分析，从而确定正常人尿液中先前未鉴定的酰基肉碱的化学结构。这些是2,6-二甲基庚酰基、2,6-二甲基-5-庚烯酰基以及反式和顺式3,4-亚甲基庚酰基肉碱，也称为3-环丙烷辛酰基肉碱。通过1H和13C核磁共振光谱对这些环丙烷衍生物的结构进行了评估。此外，还初步鉴定了其他酰基肉碱。
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