Aubert A, Goodall G, Dantzer R, Gheusi G
Domaine de Carreire, INRA-INSERM U394, Rue Camille Saint-Saëns, Bordeaux Cedex, 33077, France.
Brain Behav Immun. 1997 Jun;11(2):107-18. doi: 10.1006/brbi.1997.0485.
Behavioral symptoms of sickness that develop in response to lipopolysaccharide (LPS) and proinflammatory cytokines include depressed locomotion, anorexia, and reduced social activities. The way maternal behavior is affected in response to cytokines has, however, not yet been investigated. We checked that lactating mice are sensitive to LPS by showing that LPS- (400 microg/kg, ip) injected mice ate and drank less than saline-injected mothers and displayed a decreased rectal temperature. At an ambient temperature of 22 degrees C, nest building was significantly decreased in LPS-treated mothers compared to saline-treated animals, whereas pup retrieving, while slower, was still present and globally as efficient as for saline-treated mice. In a second experiment, dams were either injected with physiological saline or LPS but were also exposed to a cold ambient temperature (6 degrees C) or kept in standard external condition (22 degrees C). LPS-treated mice exposed to cold expressed not only pup-retrieving but also nest-building activity. These differential results indicate that the behavioral expression of LPS-induced sickness depends on the priority of the behavior under consideration.
由脂多糖（LPS）和促炎细胞因子引发的疾病行为症状包括运动减少、厌食以及社交活动减少。然而，细胞因子对母性行为的影响方式尚未得到研究。我们通过表明注射LPS（400微克/千克，腹腔注射）的小鼠比注射生理盐水的母鼠进食和饮水更少且直肠温度降低，来验证哺乳期小鼠对LPS敏感。在22摄氏度的环境温度下，与注射生理盐水的动物相比，接受LPS处理的母鼠筑巢行为显著减少，而找回幼崽的行为虽然较慢，但仍然存在，总体上与注射生理盐水的小鼠效率相当。在第二个实验中，给母鼠注射生理盐水或LPS，但也将它们暴露于寒冷的环境温度（6摄氏度）或保持在标准外部条件（22摄氏度）下。暴露于寒冷环境的LPS处理小鼠不仅表现出找回幼崽的行为，还表现出筑巢活动。这些不同的结果表明，LPS诱导疾病的行为表现取决于所考虑行为的优先级。
