Ye F Q, Smith A M, Yang Y, Duyn J, Mattay V S, Ruttimann U E, Frank J A, Weinberger D R, McLaughlin A C
Clinical Brain Disorders Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892, USA.
Neuroimage. 1997 Aug;6(2):104-12. doi: 10.1006/nimg.1997.0282.
Steady-state arterial spin tagging MRI approaches were used to quantitate regional cerebral blood flow increases during finger tapping tasks in seven normal subjects. Statistically significant increases in cerebral blood flow were observed in the contralateral primary sensorimotor cortex in all seven subjects and in the supplementary motor area in five subjects. The intrinsic spatial resolution of the cerebral blood flow images was approximately 4 mm. If no spatial filtering was applied, the average increase in cerebral blood flow in the activated primary sensorimotor cortex was 60 +/- 10 cc/100 g/min (91 +/- 32%). If the images were filtered to a spatial resolution of 15 mm, the average increase in cerebral blood flow in the activated primary sensorimotor cortex was 23 +/- 7 cc/100 g/min (42 +/- 15%), in agreement with previously reported 133Xe and PET results.
采用稳态动脉自旋标记磁共振成像方法，对7名正常受试者在手指敲击任务期间的局部脑血流增加情况进行定量分析。在所有7名受试者的对侧初级感觉运动皮层以及5名受试者的辅助运动区均观察到脑血流有统计学意义的增加。脑血流图像的固有空间分辨率约为4毫米。如果不应用空间滤波，激活的初级感觉运动皮层中脑血流的平均增加量为60±10立方厘米/100克/分钟（91±32%）。如果将图像滤波至空间分辨率为15毫米，激活的初级感觉运动皮层中脑血流的平均增加量为23±7立方厘米/100克/分钟（42±15%），这与先前报道的133Xe和正电子发射断层扫描结果一致。
