Ye F Q, Smith A M, Mattay V S, Ruttimann U E, Frank J A, Weinberger D R, McLaughlin A C
Clinical Brain Disorders Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892, USA.
Neuroimage. 1998 Jul;8(1):44-9. doi: 10.1006/nimg.1998.0342.
Steady-state arterial spin-tagging MRI approaches were used to quantitate regional cerebral blood flow increases in prefrontal cortex during a working memory ("two-back") task in six normal subjects. Statistically significant increases in cerebral blood flow in prefrontal cortex were observed in all six subjects: the average increase in cerebral blood flow in activated prefrontal cortex regions was 22 +/- 5 cc/100 g/min (23 +/- 7%). The results demonstrate that spin-tagging approaches can be used to follow focal activation in prefrontal cortex during cognitive tasks.
采用稳态动脉自旋标记磁共振成像方法，对6名正常受试者在执行工作记忆（“双回溯”）任务期间前额叶皮质局部脑血流增加情况进行定量分析。所有6名受试者前额叶皮质的脑血流均出现了具有统计学意义的增加：激活的前额叶皮质区域脑血流平均增加22±5毫升/100克/分钟（23±7%）。结果表明，自旋标记方法可用于追踪认知任务期间前额叶皮质的局灶性激活。
