[Pharmacokinetics of ampicillin in lambs and guinea pigs].

Comparative studies were carried out on the sodium salt of ampicillin and ampicillintrihydrate with the use of guinea pigs and lambs. Ampicillintrihydrate was applied to guinea pigs singly, muscularly and orally, at the rate of 0.025 per kilogram With lambs the two forms of the preparation were used--muscularly at rates of 0.005, 0.01, 0.015, and 0.02/kg; ampicillintrihydrate was tested orally at rates of 0.02, 0.03, and 0.05 kg/weight. For venous application ampicillin-sodium was used at the rate of 0.02/kg under the form of 4 per cent water solution (prepared with distilled water). Data referring to the comparative studies on the two forms of ampicillin--ampicillin-sodium and ampicillintrihydrate--showed that these preparations, after single parenteral and oral administration, are resorbed from the site of application and penetrate into all investigated organs and tissues. Ampicillin developed very soon bacteriostatic concentration in the blood serum in the course of 4-6-8 hours, depending on the amount applied and the route of application.