慢性丙型肝炎病毒感染患者的风湿性和自身免疫性表现。

Rheumatologic and autoimmune manifestations in patients with chronic hepatitis C virus infection.

作者信息

Romero Portales M, De Diego Lorenzo A, Rivera J, García Monforte A, Piqueras Alcol B, García Durán F, Cos Arregui E, Clemente Ricote G

机构信息

Service of Digestive Diseases (Hepatology Section), Gregorio Marañón General University Hospital, Madrid, Spain.

出版信息

Rev Esp Enferm Dig. 1997 Aug;89(8):591-8.

PMID:9299918

Abstract

Hepatitis C virus (HCV) has been associated with several autoimmune and rheumatologic disorders. The aim of this study was to determine the incidence of these abnormalities in patients with chronic HCV. We studied 56 patients, 29 of whom (52%) had biochemical abnormalities that suggested immunological disorders. Cryoglobulinemia was detected in nine patients (22%), antinuclear antibodies in eleven (20%), rheumatoid factor in seven (19.27%) and hypocomplementemia in fourteen (29.16%). The most common clinical manifestations were: arthralgias (52%), myalgias (16%), xerostomia (28.5%) and xerophthalmia (14%). These results indicate the existence of a relationship between HCV and rheumatologic disorders. We conclude that HCV may play a role in the pathogenesis of these autoimmune phenomena, but more studies are required to define the extent of this role.

摘要

丙型肝炎病毒（HCV）与多种自身免疫性和风湿性疾病相关。本研究的目的是确定慢性HCV患者中这些异常情况的发生率。我们研究了56例患者，其中29例（52%）有提示免疫紊乱的生化异常。9例患者（22%）检测到冷球蛋白血症，11例（20%）检测到抗核抗体，7例（19.27%）检测到类风湿因子，14例（29.16%）检测到补体低下。最常见的临床表现为：关节痛（52%）、肌痛（16%）、口干（28.5%）和干眼症（14%）。这些结果表明HCV与风湿性疾病之间存在关联。我们得出结论，HCV可能在这些自身免疫现象的发病机制中起作用，但需要更多研究来确定这一作用的程度。