氯胺酮和戊巴比妥对大鼠额叶皮质体内乙酰胆碱释放的影响。
Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo.
作者信息
Kikuchi T, Wang Y, Shinbori H, Sato K, Okumura F
机构信息
Department of Anesthesiology, Yokohama City University School of Medicine, Japan.
出版信息
Br J Anaesth. 1997 Jul;79(1):128-30. doi: 10.1093/bja/79.1.128.
We have studied the effects of ketamine and pentobarbitone on acetylcholine (ACh) release from the rat frontal cortex using microdialysis. Ketamine 25, 50 and 100 mg kg-1 increased ACh release from the frontal cortex to 286%, 253% and 381% of basal release, respectively. In contrast, pentobarbitone 10, 20 and 40 mg kg-1 caused 73%, 78% and 96% inhibition of basal levels, respectively. The results suggest that ketamine and pentobarbitone have opposite effects on ACh release from the rat frontal cortex, as seen previously in the rat hippocampus.
我们使用微透析技术研究了氯胺酮和戊巴比妥对大鼠额叶皮质乙酰胆碱（ACh）释放的影响。氯胺酮25、50和100 mg kg-1分别使额叶皮质的ACh释放增加至基础释放量的286%、253%和381%。相比之下，戊巴比妥10、20和40 mg kg-1分别导致基础水平的73%、78%和96%的抑制。结果表明，氯胺酮和戊巴比妥对大鼠额叶皮质ACh释放具有相反的作用，正如先前在大鼠海马体中所见。
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