Ciraulo A M, Alpert N, Franko K J
National Institute of Drug Abuse/Department of Veterans Affairs Medication Development Center, Boston, Massachusetts, USA.
Am Fam Physician. 1997 Sep 1;56(3):803-6.
Naltrexone is a pure opioid antagonist that is an effective nonaversive pharmacologic treatment for alcohol dependence. The usual dosage is 50 mg per day. Side effects may include nausea, headache, dizziness and arthralgia. Naltrexone appears to exert its effect by decreasing the craving for alcohol. It has also been useful in allowing some patients to decrease their need for other medications, such as benzodiazepines and antihypertensives. Naltrexone should be used as an adjunct to a comprehensive alcohol treatment program that addresses concomitant medical problems and psychosocial concerns.
纳曲酮是一种纯阿片类拮抗剂，是治疗酒精依赖有效的非厌恶药理学疗法。常用剂量为每日50毫克。副作用可能包括恶心、头痛、头晕和关节痛。纳曲酮似乎通过减少对酒精的渴望发挥作用。它还有助于一些患者减少对其他药物（如苯二氮䓬类药物和抗高血压药物）的需求。纳曲酮应用作综合酒精治疗计划的辅助手段，该计划应解决伴随的医疗问题和社会心理问题。
