司坦唑醇对患有慢性肾衰竭的去势犬身体成分、氮平衡及食物消耗的影响。
Effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.
作者信息
Cowan L A, McLaughlin R, Toll P W, Brown S A, Moore T I, Butine M D, Milliken G
机构信息
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
出版信息
J Am Vet Med Assoc. 1997 Sep 15;211(6):719-22.
OBJECTIVE
To determine the effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.
DESIGN
Blinded crossover trial.
ANIMALS
22 castrated Beagles with experimentally induced chronic renal failure.
PROCEDURE
Dogs were divided into 2 groups of 11 dogs each. During each of two 6-week treatment periods, dogs in 1 group received stanozolol, and those in the other group received a control agent. Nitrogen balance, body composition, and food consumption were determined.
RESULTS
During administration of stanozolol, the amount of food consumed per dog, lean body mass, and nitrogen balance increased. Stanozolol did not have a significant effect on body fat, bone mineral content, or food consumption per kilogram of body weight.
CLINICAL IMPLICATIONS
For dogs with mild-to-moderate, nonuremic, experimentally induced, chronic renal failure, stanozolol had positive effects on nitrogen balance and lean body mass.
目的
确定司坦唑醇对患有慢性肾衰竭的去势犬身体成分、氮平衡和食物摄入量的影响。
设计
双盲交叉试验。
动物
22只通过实验诱导患有慢性肾衰竭的去势比格犬。
方法
将犬分为两组，每组11只。在两个为期6周的治疗期的每一期中，一组犬接受司坦唑醇治疗，另一组犬接受对照剂治疗。测定氮平衡、身体成分和食物摄入量。
结果
在给予司坦唑醇期间，每只犬的食物摄入量、瘦体重和氮平衡增加。司坦唑醇对体脂、骨矿物质含量或每千克体重的食物摄入量没有显著影响。
临床意义
对于轻度至中度、非尿毒症、实验诱导的慢性肾衰竭犬，司坦唑醇对氮平衡和瘦体重有积极影响。
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