Möricke R, Marek H, Winiecki P, Mochow P, Bindseil S, Reichert E
Z Gesamte Inn Med. 1977 Jun 1;32(11):suppl 171-4.
On 645 diabetics of the treatment-groups diet (n = 180), sulfonylurea therapy (n = 250), biguanide therapy (n = 50), and insulin therapy (n = 165) the concentrations of cholesterol and triglyceride were determined and the lipoprotein electrophoresis was carried out. 29% of the diabetics showed hyperliproteinaemias, males and females in the same frequency. In about 54% the type IV was observed most frequently, then followed the types IIb with 25% and the type IIa with about 13%. The dependence of triglycerides on the metabolic situation and the body weight was proved in diabetics. The cholesterol values were independent on form of therapy, body weight and metabolic situation. In the group with sulfonylurea in about 49%, in the group with insulin in about 37% and in the group with diet and buformin only in about 32% a hyperlipoproteinaemia was proved. The opinion is represented that the high percentage of hyperlipoproteinaemia in diabetics and the connected with this additionally increased risk for vascular complications should lead to the introduction of diagnostics and therapy of hyperlipoproteinaemia into the programme of the diabetes dispensaries of the GDR. For the treatment of diabetes the principle should be taken into consideration that a diabetes is optimally regulated only then, when apart from the blood sugar values also the blood fats are within the normal.
对治疗组中采用饮食治疗(n = 180)、磺脲类药物治疗(n = 250)、双胍类药物治疗(n = 50)和胰岛素治疗(n = 165)的645名糖尿病患者,测定了胆固醇和甘油三酯浓度,并进行了脂蛋白电泳。29%的糖尿病患者出现高脂蛋白血症,男性和女性的发生率相同。在约54%的患者中最常观察到IV型,其次是IIb型(25%)和IIa型(约13%)。在糖尿病患者中证实了甘油三酯与代谢状况和体重的相关性。胆固醇值与治疗方式、体重和代谢状况无关。在磺脲类药物治疗组中约49%、胰岛素治疗组中约37%以及饮食和二甲双胍治疗组中仅约32%的患者被证实有高脂蛋白血症。有人认为,糖尿病患者中高脂蛋白血症的高比例以及与此相关的血管并发症额外增加的风险,应促使将高脂蛋白血症的诊断和治疗纳入民主德国糖尿病诊疗机构的计划中。对于糖尿病的治疗,应考虑这样一个原则,即只有当血糖值和血脂都在正常范围内时,糖尿病才能得到最佳控制。