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氯贝丁酯治疗糖尿病伴高蛋白血症(作者译)

[Clofibrate treatment of diabetics with hyperproteinemias (author's transl)].

作者信息

Jung W, Kremer G J, Müller D

出版信息

MMW Munch Med Wochenschr. 1975 Oct 31;117(44):1783-6.

PMID:171564
Abstract

The effect of a six weeks clofibrate treatment on lipid metabolism was investigated in a collective of 38 constantly maladjusted elderly diabetics with an average of 30% overweight and various forms of hyperlipoproteinemias. Clofibrate produced a significant lowering of the mean triglyceride and cholesterol levels, whereas no such effect was observed in an untreated control group. Related to the various types of hyperlipoproteinemia (IIa, IIb and IV), the group treated with clofibrate showed a rate of normalization of nearly 50%, while the rate of improvement in the untreated control group was 10%.

摘要

在一个由38名持续失调的老年糖尿病患者组成的群体中,研究了六周氯贝丁酯治疗对脂质代谢的影响。这些患者平均超重30%,并患有各种形式的高脂蛋白血症。氯贝丁酯使平均甘油三酯和胆固醇水平显著降低,而在未治疗的对照组中未观察到这种效果。与各种类型的高脂蛋白血症(IIa、IIb和IV型)相关,接受氯贝丁酯治疗的组的正常化率接近50%,而未治疗的对照组的改善率为10%。

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