[外膜素和触珠蛋白对体外循环期间溶血的影响]

[Effects of exocorpol and haptoglobin on hemolysis during ECC].

作者信息

Nagamine S, Sekino Y, Tabayashi K, Haneda K, Suzuki Y, Mohri H

出版信息

Rinsho Kyobu Geka. 1989 Aug;9(4):381-4.

PMID:9301946

Abstract

This study was performed to evaluate the effects of Exocorpol and Haptoglobin on hemolysis during ECC. We measured free hemoglobin (F-Hb) and free haptoglobin (F-Hp) at pre- and post-ECC. Patients were divided four groups: Group C, 5 patients undergoing no treatment; Group Ex, 5 patients undergoing treatment of Exocorpol; Group Hp, 5 patients undergoing treatment of Haptoglobin; Group Ex + Hp, 5 patients undergoing treatment of Exocorpol and Haptoglobin. F-Hb of pre- and post-ECC in four groups were 0 mg/dl: 85 mg/dl (Group C, p < 0.01), 0 mg/dl: 2 mg/dl (Group Ex, NS), 0 mg/dl: 1 mg/dl (Group Hp, NS), 0 mg/dl: 0 mg/dl (group Ex + Hp, NS). F-Hp of pre- and post-ECC in four groups were 143 mg/dl: 9 mg/dl (Group C, p < 0.02), 133 mg/dl: 25 mg/dl (Group Ex, p < 0.05), 186 mg/dl: 195 mg/dl (Group Hp, NS), 66 mg/dl: 163 mg/dl (Group EX + Hp, p < 0.05). There was no significant difference in F-Hb and F-Hp of pre-ECC among four groups. F-Hb of post-ECC in Group C was significantly higher than that of Group Ex, Hp and Ex + Hp (p < 0.01), and F-Hp of post-ECC in Group Hp and Ex + Hp was significantly higher than that of Group C and Ex.(p < 0.01, p < 0.02). We concluded that Exocorpol and Haptoglobin were effective on hemolysis during ECC, and combination of these was more effective.

摘要

本研究旨在评估外源性细胞色素C（Exocorpol）和触珠蛋白对体外循环（ECC）期间溶血的影响。我们在ECC前后测量了游离血红蛋白（F-Hb）和游离触珠蛋白（F-Hp）。患者被分为四组：C组，5例未接受治疗的患者；Ex组，5例接受Exocorpol治疗的患者；Hp组，5例接受触珠蛋白治疗的患者；Ex + Hp组，5例接受Exocorpol和触珠蛋白联合治疗的患者。四组患者ECC前后的F-Hb分别为：0 mg/dl：85 mg/dl（C组，p < 0.01），0 mg/dl：2 mg/dl（Ex组，无统计学意义），0 mg/dl：1 mg/dl（Hp组，无统计学意义），0 mg/dl：0 mg/dl（Ex + Hp组，无统计学意义）。四组患者ECC前后的F-Hp分别为：143 mg/dl：9 mg/dl（C组，p < 0.02），133 mg/dl：25 mg/dl（Ex组，p < 0.05），186 mg/dl：195 mg/dl（Hp组，无统计学意义），66 mg/dl：163 mg/dl（Ex + Hp组，p < 0.05）。四组患者ECC前的F-Hb和F-Hp无显著差异。C组ECC后的F-Hb显著高于Ex组、Hp组和Ex + Hp组（p < 0.01），Hp组和Ex + Hp组ECC后的F-Hp显著高于C组和Ex组（p < 0.01，p < 0.02）。我们得出结论：Exocorpol和触珠蛋白对ECC期间的溶血有效，两者联合使用效果更佳。