Kanamori Y, Tanabe H, Shimono T, Tani K, Yada I, Yuasa H, Kusagawa M
Rinsho Kyobu Geka. 1989 Oct;9(5):463-7.
It is well known that hemolysis by extracorporeal circulation is major cause of renal failure after open heart surgery. The purpose of this study is to investigate the effects of administration of haptoglobin (Hp) during extracorporeal circulation. The patients were divided into two groups: Group I 10 patients underwent open heart surgery for extracorporeal circulation; Group II 10 patients underwent open heart surgery for extracorporeal circulation with the administration of 4,000 IU of Hp. The serum level of total Hp was elevated in group II during bypass, and reduced at 1st day in both groups more than pre-operative level. The serum level of total Hb was elevated in both groups during bypass, and reduced at 1st day within normal limits. Free serum Hb was found in group I at 30 min after start bypass and increased during bypass and urinary Hb was also found. However, in group II free Hb was not found during and after bypass. Urinary NAG and alpha 1 Mg levels of group I were significantly higher than those of group II. The administration of Hp during extracorporeal circulation prevents the increment of serum free Hb and is effective for protection of renal function.
众所周知，体外循环引起的溶血是心脏直视手术后肾衰竭的主要原因。本研究的目的是探讨体外循环期间给予触珠蛋白（Hp）的效果。患者分为两组：第一组10例患者接受心脏直视手术进行体外循环；第二组10例患者接受心脏直视手术进行体外循环并给予4000 IU的Hp。在体外循环期间，第二组的血清总Hp水平升高，两组在术后第1天均较术前水平降低。两组在体外循环期间血清总血红蛋白水平均升高，并在术后第1天降至正常范围。在第一组中，体外循环开始30分钟后发现游离血清血红蛋白，且在体外循环期间升高，同时也发现了尿血红蛋白。然而，在第二组中，体外循环期间及之后均未发现游离血红蛋白。第一组的尿NAG和α1Mg水平显著高于第二组。体外循环期间给予Hp可防止血清游离血红蛋白增加，对保护肾功能有效。
