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含镁心脏停搏液对延长主动脉阻断病例的影响

[Effect of magnesium containing cardioplegic solution on the cases of extended aortic cross clamping].

作者信息

Inui K, Kobayashi M, Orita H, Shimanuki T, Kohno M, Fukasawa M, Abe K, Kuraoka S, Washio M

出版信息

Rinsho Kyobu Geka. 1989 Oct;9(5):468-71.

PMID:9301958
Abstract

We have investigated about the preservation of myocardium using magnesium containing cardioplegic solution. In this study we have concluded that magnesium containing cardioplegic solution is effective especially in the cases of extended Aortic cross clamping. 91 cases were availed for studying the post-operative cardiac function, and 32 cases of which were availed for seeking the content of calcium and magnesium of the myocardium. GK-Mg solution was superior in the post-operative cardiac function, and in the total CPK-MB. The retention of calcium in the myocardium after Ao declamping was higher in the cases of using GK solution. And Ca.Mg ratio was also higher in GK solution. Especially in the cases of extended Ao cross clamping, increase of calcium in the myocardium and Ca.Mg ratio was suppressed by using the GK.Mg solution. Although magnesium have several effects on the myocardium, but we think that suppressing the influx of calcium into the myocardium is one of the most important factor of the magnesium for the preservation of myocardium.

摘要

我们已经研究了使用含镁心脏停搏液对心肌的保护作用。在本研究中,我们得出结论,含镁心脏停搏液尤其在主动脉长时间阻断的情况下是有效的。91例患者用于研究术后心脏功能,其中32例用于检测心肌钙和镁的含量。GK-Mg液在术后心脏功能和总CPK-MB方面表现更优。在使用GK液的情况下,主动脉阻断后心肌中钙的潴留更高。并且GK液中的钙镁比也更高。尤其是在主动脉长时间阻断的情况下,使用GK-Mg液可抑制心肌中钙的增加和钙镁比。尽管镁对心肌有多种作用,但我们认为抑制钙流入心肌是镁对心肌保护的最重要因素之一。

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