Sezai Y, Atsumi K, Fujimasa I, Imachi K, Koyanagi H, Horiuchi T, Orime Y
Rinsho Kyobu Geka. 1989 Oct;9(5):478-85.
We began applying of our VAD system clinically in 1982 and have subsequently obtained good results. The first case treated with the VAD returned to normal life. In a total of 70 cases of clinical applications this system there has been instance of apparatus dysfunction. Confirming the reliability and safety promised by the results of biological experiments. Here, we report the results of clinical application of the system in a total of 61 cases between August, 1985 and March, 1989. The following conclusions were reached: 1) Satisfactory weaning and survival rates were obtained i.e. 18 cases out of 61 cases (30%) survived over one month and 13 cases (21%) are currently surviving, even in elderly patients of 60 years of age or older. 2) The weaning rate and survival rates were good after approximately 1 week of support. Detailed evaluation of the recovery of the heart and functions of other major organs has led to the conclusion that the results can be improved further when the weaning period is carefully determined. 3) With regard to surgical factors, good findings were obtained when the artificial heart-lung bypass time was less than 6 hours. The VAD can be used in the early stages without vainly attempting weaning from the artificial heart-lung bypass. 4) There were no mechanical problems with the hardware of the blood pump drive assembly, etc., or noteworthy side effects.
我们于1982年开始在临床上应用我们的VAD系统，随后取得了良好的效果。首例接受VAD治疗的患者恢复了正常生活。在总共70例该系统的临床应用中，没有出现设备功能障碍的情况。这证实了生物学实验结果所承诺的可靠性和安全性。在此，我们报告该系统在1985年8月至1989年3月期间共61例临床应用的结果。得出以下结论：1）获得了令人满意的撤机和生存率，即61例中有18例（30%）存活超过1个月，13例（21%）目前仍存活，即使是60岁及以上的老年患者。2）在大约1周的支持后，撤机率和生存率良好。对心脏和其他主要器官功能恢复的详细评估得出结论，当仔细确定撤机期时，结果可以进一步改善。3）关于手术因素，当体外循环时间少于6小时时，取得了良好的结果。VAD可以在早期使用，而不必徒劳地尝试从体外循环撤机。4）血泵驱动组件等硬件没有机械问题，也没有值得注意的副作用。
