Tcherepanov A A, Sokolov B P
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.
J Neurosci Res. 1997 Sep 1;49(5):639-44. doi: 10.1002/(SICI)1097-4547(19970901)49:5<639::AID-JNR14>3.0.CO;2-Q.
Synaptic abnormalities have been implicated in schizophrenia. In order to investigate synaptic pathology in schizophrenia, we examined levels of mRNAs encoding synaptophysin, synapsin 1A and synapsin 1B in the left temporal cortex from schizophrenics (n = 24) and from normal control individuals with no history of psychiatric illness (n = 10). Levels of synaptic mRNAs in the left superior temporal and left middle temporal gyrus declined significantly with age in schizophrenics, but not in controls. Dividing the diagnostic groups according to age (below and above 75 years), the data revealed that in "young" schizophrenics (age <75 years) levels of the three synaptic mRNAs in the left superior and left middle temporal gyri were approximately two times higher than in the age-matched controls. In the "old" schizophrenics (age >75 years) the levels of synaptic mRNAs in temporal cortex did not differ from age-matched controls. These findings further support the hypothesis that developmental synaptic abnormalities may be involved in the pathophysiology of schizophrenia.
突触异常与精神分裂症有关。为了研究精神分裂症中的突触病理学，我们检测了精神分裂症患者（n = 24）和无精神疾病史的正常对照个体（n = 10）左侧颞叶皮质中编码突触素、突触结合蛋白1A和突触结合蛋白1B的mRNA水平。精神分裂症患者左侧颞上回和颞中回的突触mRNA水平随年龄显著下降，而对照组则不然。根据年龄（75岁以下和以上）对诊断组进行划分，数据显示，在“年轻”精神分裂症患者（年龄<75岁）中，左侧颞上回和颞中回的三种突触mRNA水平比年龄匹配的对照组高约两倍。在“老年”精神分裂症患者（年龄>75岁）中，颞叶皮质的突触mRNA水平与年龄匹配的对照组没有差异。这些发现进一步支持了发育性突触异常可能参与精神分裂症病理生理学的假说。
