血凝作用是脂多糖（LPS）的一种新的生物学功能，霍乱弧菌O139 LPS就是如此。
Hemagglutination is a novel biological function of lipopolysaccharide (LPS), as seen with the Vibrio cholerae O139 LPS.
作者信息
Alam M, Miyoshi S, Tomochika K, Shinoda S
机构信息
Faculty of Pharmaceutical Sciences, Okayama University, Naka, Japan.
出版信息
Clin Diagn Lab Immunol. 1997 Sep;4(5):604-6. doi: 10.1128/cdli.4.5.604-606.1997.
Abstract
It has been generally thought that the polysaccharide moiety of lipopolysaccharide (LPS) maintains only serological specificity, while the lipid A portion determines various biological functions. However, we found that hemagglutination was a common function of the polysaccharide moiety of LPSs from important human enteropathogenic bacteria. Of the LPSs examined, Vibrio cholerae O139 LPS showed the highest hemagglutinating activity. Glycoproteins, such as mucin and fetuin, showed efficient inhibition of the hemagglutinating ability. Since cell-mediated hemagglutination is known to be correlated with bacterial adherence, hemagglutination induced by the polysaccharide moiety is interpreted to indicate that cell-surface LPS is a potential adhesin.
摘要
人们普遍认为，脂多糖（LPS）的多糖部分仅维持血清学特异性，而脂质A部分决定各种生物学功能。然而，我们发现血凝是来自重要人类肠道病原菌的LPS多糖部分的共同功能。在所检测的LPS中，霍乱弧菌O139 LPS表现出最高的血凝活性。糖蛋白，如粘蛋白和胎球蛋白，对血凝能力有有效的抑制作用。由于已知细胞介导的血凝与细菌粘附相关，多糖部分诱导的血凝被解释为表明细胞表面LPS是一种潜在的粘附素。
相似文献
1
Hemagglutination is a novel biological function of lipopolysaccharide (LPS), as seen with the Vibrio cholerae O139 LPS.血凝作用是脂多糖（LPS）的一种新的生物学功能，霍乱弧菌O139 LPS就是如此。
Clin Diagn Lab Immunol. 1997 Sep;4(5):604-6. doi: 10.1128/cdli.4.5.604-606.1997.
2
A comparative study of the properties of Vibrio cholerae O139, O1 and other non-O1 strains.霍乱弧菌O139、O1及其他非O1菌株特性的比较研究
J Med Microbiol. 1995 Apr;42(4):251-7. doi: 10.1099/00222615-42-4-251.
3
Lipopolysaccharides of Vibrio cholerae: III. Biological functions.
Biochim Biophys Acta. 2006 Jan;1762(1):1-16. doi: 10.1016/j.bbadis.2005.08.005. Epub 2005 Sep 2.
4
The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants.霍乱弧菌O139血清群抗原包括O抗原荚膜和脂多糖毒力决定簇。
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11388-92. doi: 10.1073/pnas.91.24.11388.
5
Characterizing lipopolysaccharide and core lipid A mutant O1 and O139 Vibrio cholerae strains for adherence properties on mucus-producing cell line HT29-Rev MTX and virulence in mice.对脂多糖和核心脂质A突变的O1和O139霍乱弧菌菌株进行特性分析，以研究其在产生黏液的细胞系HT29-Rev MTX上的黏附特性以及在小鼠中的毒力。
Int J Med Microbiol. 2005 Aug;295(4):243-51. doi: 10.1016/j.ijmm.2005.05.002.
6
Structural studies on the short-chain lipopolysaccharide of Vibrio cholerae O139 Bengal.霍乱弧菌O139孟加拉型短链脂多糖的结构研究。
Eur J Biochem. 1997 Jul 1;247(1):402-10. doi: 10.1111/j.1432-1033.1997.00402.x.
7
Purification and characterization of novel hemagglutinins from Vibrio mimicus: a 39-kilodalton major outer membrane protein and lipopolysaccharide.模仿弧菌新型血凝素的纯化与特性分析：一种39千道尔顿的主要外膜蛋白和脂多糖
Infect Immun. 1996 Oct;64(10):4035-41. doi: 10.1128/iai.64.10.4035-4041.1996.
8
An immunochemical study of serological cross-reaction between lipopolysaccharides from Vibrio cholerae O22 and O139.霍乱弧菌O22和O139脂多糖之间血清学交叉反应的免疫化学研究。
Microbiology (Reading). 1996 Jun;142 ( Pt 6):1499-1504. doi: 10.1099/13500872-142-6-1499.
9
Biological activities of lipopolysaccharide isolated from Vibrio cholerae O139, a new epidemic strain for recent cholera in Indian subcontinent.
Microbiol Immunol. 1994;38(6):471-4. doi: 10.1111/j.1348-0421.1994.tb01810.x.
10
O-antigenic lipopolysaccharide of Vibrio cholerae O139 Bengal, a new epidemic strain for recent cholera in the Indian subcontinent.霍乱弧菌O139孟加拉型的O抗原脂多糖，印度次大陆近期霍乱的一种新流行菌株。
Biochem Biophys Res Commun. 1993 Nov 15;196(3):1309-15. doi: 10.1006/bbrc.1993.2395.
引用本文的文献
1
Effect of parenteral endotoxin administration on the immuno-haematological responses of catfish.注射内毒素对鲶鱼免疫血液学反应的影响。
Fish Shellfish Immunol Rep. 2021 Aug 29;2:100022. doi: 10.1016/j.fsirep.2021.100022. eCollection 2021 Dec.
2
Induction of phenoloxidase and other immunological activities in the humoral fluids of amphioxus Branchiostoma belcheri challenged with Lipopolysaccharide (LPS).文昌鱼（Branchiostoma belcheri）体液中酚氧化酶及其他免疫活性物质的诱导及其对脂多糖（LPS）的反应。
Fish Physiol Biochem. 2012 Dec;38(6):1835-1842. doi: 10.1007/s10695-012-9680-7. Epub 2012 Jun 26.
3
Vibrio cholerae O139 requires neither capsule nor LPS O side chain to grow inside Acanthamoeba castellanii.霍乱弧菌O139在卡氏棘阿米巴中生长既不需要荚膜也不需要脂多糖O侧链。
J Med Microbiol. 2009 Jan;58(Pt 1):125-131. doi: 10.1099/jmm.0.004721-0.
本文引用的文献
1
Purification and characterization of novel hemagglutinins from Vibrio mimicus: a 39-kilodalton major outer membrane protein and lipopolysaccharide.模仿弧菌新型血凝素的纯化与特性分析：一种39千道尔顿的主要外膜蛋白和脂多糖
Infect Immun. 1996 Oct;64(10):4035-41. doi: 10.1128/iai.64.10.4035-4041.1996.
2
Expression of virulence-related properties by, and intestinal adhesiveness of, Vibrio mimicus strains isolated from aquatic environments.从水生环境分离的拟态弧菌菌株的毒力相关特性表达及肠道黏附性
Appl Environ Microbiol. 1996 Oct;62(10):3871-4. doi: 10.1128/aem.62.10.3871-3874.1996.
3
Lack of cross-protection against diarrhea due to Vibrio cholerae O139 (Bengal strain) after oral immunization of rabbits with V. cholerae O1 vaccine strain CVD103-HgR.用霍乱弧菌O1疫苗株CVD103-HgR对兔进行口服免疫后，缺乏针对霍乱弧菌O139（孟加拉菌株）所致腹泻的交叉保护作用。
J Infect Dis. 1994 Jan;169(1):230-1. doi: 10.1093/infdis/169.1.230.
4
Outbreak of Vibrio cholerae non-O1 in India and Bangladesh.印度和孟加拉国非O1群霍乱弧菌的暴发。
Lancet. 1993 May 22;341(8856):1346-7. doi: 10.1016/0140-6736(93)90855-b.
5
Biological activities of lipopolysaccharide isolated from Vibrio cholerae O139, a new epidemic strain for recent cholera in Indian subcontinent.
Microbiol Immunol. 1994;38(6):471-4. doi: 10.1111/j.1348-0421.1994.tb01810.x.
6
Correlation between cell-associated mannose-sensitive hemagglutination by Vibrio parahaemolyticus and adherence to a human colonic cell line Caco-2.副溶血性弧菌细胞相关甘露糖敏感血凝反应与对人结肠癌细胞系Caco-2黏附之间的相关性
FEMS Microbiol Lett. 1994 Jul 1;120(1-2):207-10. doi: 10.1111/j.1574-6968.1994.tb07032.x.
7
Epidemic isolates of Vibrio cholerae 0139 express antigenically distinct types of colonization pili.霍乱弧菌0139的流行菌株表达抗原性不同类型的定居菌毛。
FEMS Microbiol Lett. 1994 May 15;118(3):265-71. doi: 10.1111/j.1574-6968.1994.tb06839.x.
8
Vibrio cholerae O139 Bengal.霍乱弧菌O139孟加拉型
J Clin Microbiol. 1994 Oct;32(10):2345-9. doi: 10.1128/jcm.32.10.2345-2349.1994.
9
Purification and characterization of a cell-associated hemagglutinin of Vibrio parahaemolyticus.副溶血性弧菌细胞相关血凝素的纯化与特性分析
Infect Immun. 1995 May;63(5):1987-92. doi: 10.1128/iai.63.5.1987-1992.1995.
10
The OmpU outer membrane protein, a potential adherence factor of Vibrio cholerae.外膜蛋白OmpU是霍乱弧菌的一种潜在黏附因子。
Infect Immun. 1995 Nov;63(11):4433-8. doi: 10.1128/iai.63.11.4433-4438.1995.
Zotero 插件