Roeckel I E, Baker J
Central Kentucky Blood Center, Lexington 40504, USA.
Ann Clin Lab Sci. 1997 Sep-Oct;27(5):346-50.
Prior to 1979, bone marrow transplants were only performed with histocompatible sibling donors. Once it was established that histocompatible, unrelated donors could donate marrow for transplantation, the recruitment of such donors needed to be standardized. Blood donor centers had already identified the histocompatibility locus antigen (HLA) typing for donors who could be recruited to donate bone marrow. Recruiting a large number of donors required systematic evaluation and testing according to defined standards which were published in 1988 by the National Marrow Donor Program (NMDP). Peripheral stem cell collection (PBS) has been added as a transplant source. It promises additional therapeutic modalities, such as gene splicing to address other than cancer therapy.
1979年以前，骨髓移植仅在组织相容性匹配的同胞供体之间进行。一旦确定组织相容性匹配的非亲属供体也可以捐献骨髓用于移植，就需要对这类供体的招募进行规范。血液中心已经为那些可以被招募来捐献骨髓的供体确定了组织相容性位点抗原（HLA）分型。招募大量供体需要按照1988年国家骨髓捐献计划（NMDP）发布的既定标准进行系统评估和检测。外周血干细胞采集（PBS）已被添加为一种移植来源。它有望带来更多的治疗方式，比如用于癌症治疗以外领域的基因拼接。
