结核分枝杆菌异烟肼耐药临床分离株中ahpC基因突变分析
Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
作者信息
Kelley C L, Rouse D A, Morris S L
机构信息
Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.
出版信息
Antimicrob Agents Chemother. 1997 Sep;41(9):2057-8. doi: 10.1128/AAC.41.9.2057.
Abstract
The ahpC genes of 57 clinical isolates and one in vitro mutant of Mycobacterium tuberculosis were evaluated by nucleotide sequence analyses. Although compensatory ahpC promoter mutations were identified in 8 catalase-negative, katG-defective strains, the ahpC genes of 25 catalase-positive, isoniazid-resistant isolates and 25 drug-sensitive strains were not altered.
摘要
通过核苷酸序列分析对57株结核分枝杆菌临床分离株和1株体外突变株的ahpC基因进行了评估。虽然在8株过氧化氢酶阴性、katG缺陷型菌株中鉴定出了补偿性ahpC启动子突变，但25株过氧化氢酶阳性、异烟肼耐药分离株和25株药物敏感菌株的ahpC基因未发生改变。
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本文引用的文献
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Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis.氧化应激反应及其在分枝杆菌对异烟肼敏感性中的作用：耻垢分枝杆菌中过氧化物对ahpC的特性及诱导作用，以及在金色分枝杆菌和结核分枝杆菌中ahpC的不表达
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J Infect Dis. 1996 Jan;173(1):196-202. doi: 10.1093/infdis/173.1.196.
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