铁（III）螯合剂吡哆醛异烟酰腙的细胞毒性类似物：与铜（II）、镓（III）和铁（III）络合对其抗增殖活性的影响
Cytotoxic analogs of the iron(III) chelator pyridoxal isonicotinoyl hydrazone: effects of complexation with copper(II), gallium(III), and iron (III) on their antiproliferative activities.
作者信息
Richardson D R
机构信息
Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, Montréal, Québec, Canada.
出版信息
Antimicrob Agents Chemother. 1997 Sep;41(9):2061-3. doi: 10.1128/AAC.41.9.2061.
Abstract
This study examined if complexation with metals increased the antiproliferative activities of chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class. Addition of iron(III) to some PIH analogs markedly depressed their activities, whereas it had little effect on others. The gallium(III) complex of PIH, but not its copper(II) complex, was more efficient than the apochelator at inhibiting [3H]thymidine incorporation.
摘要
本研究考察了与金属络合是否会增强吡啶醛异烟酰腙（PIH）类螯合剂的抗增殖活性。向一些PIH类似物中添加铁（III）会显著降低其活性，而对其他类似物影响不大。PIH的镓（III）络合物而非其铜（II）络合物在抑制[3H]胸腺嘧啶核苷掺入方面比游离螯合剂更有效。
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本文引用的文献
1
2
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Blood. 1993 Sep 1;82(5):1608-17.
3
4
5
6
Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.活化博来霉素。一种由药物、铁和氧形成的短暂复合物，可降解DNA。
J Biol Chem. 1981 Nov 25;256(22):11636-44.
7
In vitro and in vivo effects of deferoxamine in neonatal acute leukemia.去铁胺对新生儿急性白血病的体外和体内作用
Blood. 1987 Mar;69(3):757-61.
8
Cytotoxic effects of the lipophilic iron chelator omadine.亲脂性铁螯合剂奥马汀的细胞毒性作用。
FEBS Lett. 1986 Aug 18;204(2):208-12. doi: 10.1016/0014-5793(86)80813-4.
9
Colorimetric detection of the hydroxyl radical: comparison of the hydroxyl-radical-generating ability of various iron complexes.羟基自由基的比色检测：各种铁配合物产生羟基自由基能力的比较
Anal Biochem. 1988 May 15;171(1):47-54. doi: 10.1016/0003-2697(88)90123-6.
10
Deferoxamine inhibition of human neuroblastoma viability and proliferation.
Cancer Res. 1988 Dec 15;48(24 Pt 1):7189-92.
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