Moosmann B, Uhr M, Behl C
Max-Planck-Institute of Psychiatry, Clinical Institute, Munich, Germany.
FEBS Lett. 1997 Aug 25;413(3):467-72. doi: 10.1016/s0014-5793(97)00961-7.
Estrogens can protect neurons against oxidative stress-induced cell death due to their antioxidant potential. Here, we report that other aromatic alcohols with intact phenolic groups and different phenol derivatives can also protect neurons against oxidative cell death induced by glutamate and hydrogen peroxide in vitro. This neuroprotective activity was independent of the time the compound was added before the toxin. Methylation of the phenolic hydroxyl group led to a decrease or loss in neuroprotection. Moreover, the tested compounds directly inhibited peroxidation reactions, suggesting that neuroprotection is mediated by their antioxidant properties.
雌激素因其抗氧化潜能可保护神经元免受氧化应激诱导的细胞死亡。在此，我们报告称，其他具有完整酚羟基的芳香醇和不同的酚衍生物在体外也能保护神经元免受谷氨酸和过氧化氢诱导的氧化细胞死亡。这种神经保护活性与毒素添加前化合物的添加时间无关。酚羟基的甲基化导致神经保护作用减弱或丧失。此外，所测试的化合物直接抑制过氧化反应，这表明神经保护作用是由其抗氧化特性介导的。
