Alabovskiĭ V V, Vinokurov A A
Fiziol Zh (1994). 1997;43(3-4):48-53.
Calcium repletion (2.0 mM) after 10 min of calcium depletion (pCa = 7) resulted in the loss of myoglobin, decreased contents of ATP and adeninucleotides. Adenosine in concentration 50-1000 mcM depressed the release of myoglobin and prevented depletion of ATP and adenine nucleotides during the "calcium paradox". Theophylline, a non-selective A1-receptors blocker did not alter either "calcium paradox" development or protective effect of adenosine. Dipiridamole, an inhibitor of transmembrane transport of adenosine, protected hearts against the "calcium paradox" depending on the concentration. Dipiridamole (50 mcM) abolished protective effect of high concentrations (100-1000 mcM) of adenosine. The results obtained prove that transmembrane transport of adenosine is more important than its interaction with receptors for its protective effect under the "calcium paradox".
在钙耗竭（pCa = 7）10分钟后补充钙（2.0 mM）导致肌红蛋白丢失、ATP和腺嘌呤核苷酸含量降低。浓度为50 - 1000 μM的腺苷可抑制肌红蛋白释放，并防止在“钙反常”过程中ATP和腺嘌呤核苷酸耗竭。茶碱，一种非选择性A1受体阻滞剂，既不改变“钙反常”的发展，也不改变腺苷的保护作用。双嘧达莫，一种腺苷跨膜转运抑制剂，根据浓度不同可保护心脏免受“钙反常”影响。双嘧达莫（50 μM）消除了高浓度（100 - 1000 μM）腺苷的保护作用。所得结果证明，在“钙反常”情况下，腺苷的跨膜转运对其保护作用比其与受体的相互作用更为重要。
