Alabovskiĭ V V, Vinokurov A A
N. N. Burdenko Medical Institute, Ministry of Public Health of Russian Federation, Voronezh.
Fiziol Zh (1994). 1998;44(1-2):58-63.
The interrelationship between contracture development and heart damage during the calcium paradox under different sodium concentration in Ca-free media was studied on isolated rat hearts. It had been shown that calcium paradox development accompanied contracture development, intensive membrane disruption and alteration of tissue energy state. We had not found relation between contracture magnitude and degree of myocardial alterations in calcium paradox. Our dates confirm so-called intracellular hypothesis of calcium paradox. The experiments had shown close correlation between transmembrane sodium gradient in Ca-free media and degree of cellular damage and energy state alterations during calcium readmission in solution.
在无钙培养基中不同钠浓度条件下，利用离体大鼠心脏研究了钙反常过程中挛缩发展与心脏损伤之间的相互关系。结果表明，钙反常的发展伴随着挛缩的发展、强烈的膜破坏以及组织能量状态的改变。我们未发现钙反常中挛缩程度与心肌改变程度之间存在关联。我们的数据证实了所谓的钙反常细胞内假说。实验表明，无钙培养基中的跨膜钠梯度与再灌注钙溶液过程中的细胞损伤程度及能量状态改变密切相关。
