[Blood eosinophilia and immunoglobulin E: the characteristics of their regulation in helminthiases and allergic diseases].

Patients with eosinophilia (due to helminthic infections in 44 patients, to allergic diseases in 32, and to unknown causes in 37) were studied and followed up at the in- and outpatient departments of the E. I. Martsinovskiĭ Institute. Conventional laboratory studies and several parasitological, serological and image techniques were used in each case. During surveillance made during 1994 and 9 months of 1995, 11 patients (8 with toxocariasis) of the last group were replaced in the first one, 9 patients were found to have atopic diseases, and 3 patients were diagnosed as having lymphoma or blood diseases. Yet, the origin of eosinophilia remained unclear in 14 patients, 12 of whom were studied at the inpatient department of the E. I. Martsinovskiĭ Institute. The regulatory features of immune responses were analyzed in helminthic and allergic diseases by reviewing vast recent experimental data. Conceivably, comparative estimation of serum IgE/IgG4 ratios in these two groups of patients may be helpful in limiting the field of search and the time of an examination/analysis.