Worrall B B, Moazami G, Odel J G, Behrens M M
Department of Neurology, Columbia Presbyterian Medical Center, New York, New York 10032-2603, USA.
J Neuroophthalmol. 1997 Sep;17(3):162-5.
Nonarteritic anterior ischemic optic neuropathy (AION) is a well-described entity that is believed to be caused by abnormal anatomy of the optic disc and to be precipitated by several stressors or disease states. Activated protein C resistance (APCR) is a recently described mutation of factor V (FV) gene that renders FV resistant to cleavage by activated protein C. APCR predisposes to thrombotic events. The case of a 61-year-old woman with AION and activated protein C resistance is presented, and the management is discussed. We thoroughly review the literature on these two conditions. We propose that a prospective analysis of the potential role of APCR in some cases of AION is needed and suggest that physicians consider this and other prothrombotic states when evaluating patients with AION.
非动脉炎性前部缺血性视神经病变（AION）是一种已被充分描述的疾病，被认为是由视盘解剖结构异常引起的，并由多种应激因素或疾病状态诱发。活化蛋白C抵抗（APCR）是最近发现的因子V（FV）基因突变，使FV对活化蛋白C的裂解产生抵抗。APCR易引发血栓形成事件。本文介绍了一名患有AION和活化蛋白C抵抗的61岁女性病例，并讨论了其治疗方法。我们全面回顾了关于这两种疾病的文献。我们建议对APCR在某些AION病例中的潜在作用进行前瞻性分析，并建议医生在评估AION患者时考虑这种情况以及其他血栓前状态。
