Reynolds G P
Department of Biomedical Science, University of Sheffield, UK.
J Psychopharmacol. 1997;11(3):195-9. doi: 10.1177/026988119701100301.
This is an exciting time for research into the drug treatment of schizophrenia. Modern techniques in imaging and molecular biology have contributed to our understanding of the receptor mechanisms of antipsychotic drug action. Several new antipsychotics are, or will shortly be, available and each of these new drugs promise improvements over classical antipsychotics. This review will discuss the concept of atypicality in antipsychotic drugs, and will describe some of the models for identification of improved antipsychotic action. The various receptor mechanisms proposed to underlie atypical antipsychotic action, several of which have featured in recent debates in this journal, will be considered in the light of the pharmacology of some of the newly-emerging antipsychotic drugs.
这是精神分裂症药物治疗研究的一个激动人心的时期。成像和分子生物学的现代技术有助于我们理解抗精神病药物作用的受体机制。几种新型抗精神病药物已经或即将上市，每种新药都有望比传统抗精神病药物有所改进。本综述将讨论抗精神病药物非典型性的概念，并描述一些用于识别改善抗精神病作用的模型。鉴于一些新出现的抗精神病药物的药理学，将考虑为非典型抗精神病作用提出的各种受体机制，其中一些机制在本杂志最近的辩论中有所涉及。
