Svensson P, Houe L, Arendt-Nielsen L
Department of Prosthetic Dentistry, Aarhus University, Denmark.
Exp Brain Res. 1997 Aug;116(1):182-5. doi: 10.1007/pl00005738.
The effects of bilateral experimental muscle pain on human masticatory patterns were studied. Jaw movements and electromyographic (EMG) recordings of the jaw-closing muscles were divided into multiple single masticatory cycles and analyzed on a cycle-by-cycle basis. In ten men simultaneous bilateral injections of hypertonic saline (5%) into the masseter muscles caused strong pain (mean+/-SE: 7.5+/-0.4 on a 0-10 scale), significantly reduced EMG activity of jaw-closing muscles in the agonist phase, and significantly increased EMG activity in the antagonist phase. Nine of the subjects reported a sensation of less intense mastication during pain. Injections of isotonic saline (0.9%) did not cause pain or significant changes in masticatory patterns. The influence of higher brain centers on conscious human mastication can not be discarded but the observed phase-dependent modulation could be controlled by local neural circuits and/or a central pattern generator in the brain stem which are capable of integrating bilateral nociceptive afferent activity.
研究了双侧实验性肌肉疼痛对人类咀嚼模式的影响。将下颌运动和咬肌的肌电图（EMG）记录划分为多个单个咀嚼周期，并逐周期进行分析。在10名男性中，同时向咬肌双侧注射高渗盐水（5%）会引起强烈疼痛（0-10分制下的平均值±标准误：7.5±0.4），显著降低了主动收缩期咬肌的EMG活动，并显著增加了拮抗期的EMG活动。9名受试者报告在疼痛期间咀嚼感觉不那么强烈。注射等渗盐水（0.9%）不会引起疼痛或咀嚼模式的显著变化。虽然不能排除高级脑中枢对人类有意识咀嚼的影响，但观察到的相位依赖性调节可能由局部神经回路和/或脑干中的中枢模式发生器控制，这些神经回路和/或中枢模式发生器能够整合双侧伤害性传入活动。
