Langewitz W, Wössmer B, Iseli J, Berger W
Department of Internal Medicine, University Hospital Basle, Switzerland.
Diabetes Res Clin Pract. 1997 Sep;37(3):157-64. doi: 10.1016/s0168-8227(97)00071-5.
To be the master of their disease and not its slave is the ultimate goal of many patients with diabetes. Intensified functional insulin therapy (FIT) helps to establish this goal by an intensive patient education: each patient learns in five small-group sessions how s/he reacts to standardized challenges of glucose homeostasis (e.g. 24 h fasting; physical exercise; various carbohydrate loads). We investigated in 43 patients with long-standing diabetes type 1 (mean age: 33 +/- 10 years; mean duration of diabetes: 15 +/- 10 years) whether FIT improves quality of life, influences metabolic control and doctor-patient relationship. The following instruments were used: diabetes specific quality of life questionnaire (DQOL), hierarchical distance and cohesion between doctor and patient (FAST), anxiety and depression (HAD). Pre and post intervention values were compared with paired t-tests. HbA1c and number of hypoglycaemic episodes were also assessed 1 year after FIT and 1 year prior to FIT. Metabolic control was improved: HbA1c in the year before FIT: 6.72 +/- 1.35; 4 months before FIT: 6.61 +/- 1.46; 4 months after FIT: 6.29 +/- 1.09 (P < 0.05 compared to 4 months before FIT); 1 year after FIT: 6.46 +/- 1.12 (n.s. compared to 1 year before FIT). Dissatisfaction with life decreases from 33.3 +/- 8.0 to 28.5 +/- 7.7 (P < 0.001). Moments free of disease-specific strain increase from 74.3 +/- 13.9 to 78.1 +/- 16.1 (P = 0.07). Hierarchical distance between doctor and patient decreases from 1.1 +/- to 0.6 +/- 0.8 (P < 0.001), cohesion increases from 9.3 +/- 1.5 to 9.9 +/- 1.1 (P < 0.001). Anxiety and depression both decreases significantly: anxiety, 6.5 +/- 3.3-->4.6 +/- 3.2 (P < 0.001); depression, 2.7 +/- 2.5-->1.5 +/- 1.6 (P < 0.001). The number of patients with severe hypoglycaemic episodes (level 4) decreases from five (11.6%) to one (2.3%) after intervention (P < 0.05). In conclusion, FIT enhances quality of life in diabetic individuals. It helps to establish a less hierarchical and closer relationship between patient and doctor as revealed by the FAST data. It should be emphasized that the psychological improvements are not achieved at the expense of less strict metabolic control.
成为疾病的主人而非其奴隶是许多糖尿病患者的终极目标。强化功能性胰岛素治疗(FIT)通过强化患者教育有助于实现这一目标:每位患者在五次小组会议中学习自己对葡萄糖稳态标准化挑战(如24小时禁食;体育锻炼;各种碳水化合物负荷)的反应。我们对43例长期1型糖尿病患者(平均年龄:33±10岁;平均糖尿病病程:15±10年)进行了研究,以探讨FIT是否能改善生活质量、影响代谢控制以及医患关系。使用了以下工具:糖尿病特异性生活质量问卷(DQOL)、医患之间的层级距离和凝聚力(FAST)、焦虑和抑郁(HAD)。干预前后的值采用配对t检验进行比较。还在FIT后1年和FIT前1年评估了糖化血红蛋白(HbA1c)和低血糖发作次数。代谢控制得到改善:FIT前一年的HbA1c为6.72±1.35;FIT前4个月为6.61±1.46;FIT后4个月为6.29±1.09(与FIT前4个月相比,P<0.05);FIT后1年为6.46±1.12(与FIT前1年相比,无统计学意义)。对生活的不满从33.3±8.0降至28.5±7.7(P<0.001)。无疾病特异性压力的时刻从74.3±13.9增加到78.1±16.1(P = 0.07)。医患之间的层级距离从1.1±降至0.6±0.8(P<0.001),凝聚力从9.3±1.5增加到9.9±1.1(P<0.001)。焦虑和抑郁均显著降低:焦虑从6.5±3.3降至4.6±3.2(P<0.001);抑郁从2.7±2.5降至1.5±1.6(P<0.001)。干预后严重低血糖发作(4级)的患者人数从5例(11.6%)降至1例(2.3%)(P<0.05)。总之,FIT提高了糖尿病患者的生活质量。正如FAST数据所示,它有助于在患者和医生之间建立一种层级性较低且更紧密的关系。应该强调的是,心理方面的改善并非以代谢控制不那么严格为代价而实现的。