Vesa T H, Lember M, Korpela R
University of Turku, Department of Biochemistry and Food Chemistry, Finland.
Eur J Clin Nutr. 1997 Sep;51(9):633-6. doi: 10.1038/sj.ejcn.1600460.
This study investigated the role of the fat content of milk on symptoms of lactose intolerance.
Subjects recorded intolerance symptoms using a visual analogue scale (VAS) following ingestion of three test milks for varying fat content for a two-day period.
SUBJECTS/SETTING: The subjects were thirty adult volunteers, patients of two Estonian out-patient clinics with diagnosed lactose intolerance. The study milks were drunk at home or at work. All thirty subjects completed the study protocol.
Each subject drank, in random order, fat-free milk (4.9% lactose), high-fat milk (8% fat, 4.9% lactose), and a lactose-free and fat-free control milk. They drank 200 ml of the milk twice a day for two days, one milk type per session, with five days between sessions. The subjects noted their gastrointestinal symptoms during the test periods and during a 5 d milk-free period at the beginning of the study. The occurrence and severity of symptoms were compared. A global measure of the severity of symptoms was defined by computing the sum of the symptoms scores.
The sum of symptoms was higher during all milk periods than during the milk-free period (P < 0.01). There were no statistically significant differences in the occurrence or severity of symptoms during the fat-free milk period compared with the high-fat milk period.
Even a marked difference in the fat content of milk did not affect the symptoms of lactose intolerance. Consequently, there seems to be no case for recommending full-fat milk products in the treatment of lactose intolerance.
本研究调查了牛奶脂肪含量对乳糖不耐受症状的作用。
受试者在摄入三种脂肪含量不同的测试牛奶后，使用视觉模拟量表（VAS）记录为期两天的不耐受症状。
受试者/研究环境：受试者为30名成年志愿者，是两家爱沙尼亚门诊诊所诊断为乳糖不耐受的患者。研究用牛奶在家庭或工作场所饮用。所有30名受试者均完成了研究方案。
每位受试者随机饮用脱脂牛奶（乳糖含量4.9%）、高脂牛奶（脂肪含量8%，乳糖含量4.9%）和无乳糖脱脂对照牛奶。他们每天饮用两次200毫升牛奶，持续两天，每次饮用一种牛奶，两次饮用之间间隔五天。受试者记录了测试期间以及研究开始时无牛奶饮用的5天期间的胃肠道症状。比较症状的发生情况和严重程度。通过计算症状评分总和来定义症状严重程度的总体衡量指标。
所有饮用牛奶期间的症状总和均高于无牛奶饮用期间（P < 0.01）。与高脂牛奶期间相比，脱脂牛奶期间症状的发生情况或严重程度无统计学显著差异。
即使牛奶的脂肪含量存在显著差异，也不会影响乳糖不耐受症状。因此，在乳糖不耐受的治疗中，似乎没有理由推荐全脂牛奶产品。
