Evrard E, Molders V, de Bruyn-Mottard A M, Reznik M
Acta Psychiatr Belg. 1977 Jul-Aug;77(4):429-45.
The authors have observed the evolution of a late catatonic syndrome in a 50 years old woman, without psychological background. They have observed a progressive mental (intellectual) deterioration which have had for a long time a partial and paradoxical aspect, while on the thymic and affective stade an atypical melancolic picture evolved toward a schizophrenic syndrome with catatonic traits which finally came to a stade of marasmus and death after three and a half years of illness. A psychological examination performed at mid course confirmed the mental deterioration without intellectual disorganisation (Wechler) while the Rorschach indicated schizophrenia. The neuro-radiological explorations, repeated several times, have demonstrated the existence of a diffuse cerebral atrophy on the white substance and yet more on the cortex, and it was possible to follow the aggravation of this atrophy. Repeated biological tests were less informative: albumine in the CSF was 0.15 to 0.63 g % and an isolated increase of alpha1-globulines in the CSF was observed at the electrophoresis 4 months before the exitus. Histological examination of cortical biopsies and of the white substance indicates a degenerative encephalopathy with spongiosis and cortical atrophy. Because of the limited value of the histopathological examination, one cannot suggest a systematic interpretation of the catatonic symptoms.
作者观察了一名50岁无心理背景女性迟发性紧张症综合征的演变过程。他们观察到一种进行性精神（智力）衰退，长期以来呈现出部分且矛盾的特征，而在情绪和情感阶段，一种非典型的抑郁状态逐渐演变为具有紧张症特征的精神分裂症综合征，最终在患病三年半后进入消瘦和死亡阶段。病程中期进行的心理检查证实存在精神衰退但无智力紊乱（韦氏量表），而罗夏墨迹测验显示为精神分裂症。多次重复的神经放射学检查表明，白质以及更多的皮质存在弥漫性脑萎缩，并且能够观察到这种萎缩的加重情况。多次重复的生物学检测提供的信息较少：脑脊液中的白蛋白为0.15至0.63g%，在死亡前4个月的电泳检查中观察到脑脊液中α1球蛋白单独升高。皮质活检和白质的组织学检查表明为伴有海绵状变性和皮质萎缩的退行性脑病。由于组织病理学检查价值有限，无法对紧张症症状进行系统性解释。
