Tanaka S, Asao T, Ubukata M, Sugiyama H, Yajima Y, Takenoshita S, Nagamachi Y
Department of Surgery I, Gunma University School of Medicine, Maebashi, Japan.
Surg Today. 1997;27(7):623-6. doi: 10.1007/BF02388218.
The use of Tc-99m hexakis 2-methoxy isobutyl isonitrile (MIBI) scintigraphy for qualitative diagnosis was examined. A total of 37 lesions from 31 patients with respiratory disease (19 lesions from 19 primary lung cancer patients, 8 lesions from 3 metastatic lung cancer patients and 10 lesions from benign lung disease patients) were examined. Positive results were seen in 89.4% of the primary lung cancer lesions, 50.0% of the metastatic lung cancer lesions, and 20.0% of the benign lung disease lesions. The positive rate of 77.7% for malignant lung cancer was significantly higher (P < 0.01) than that for benign lung cancer. In particular, for lesions with a tumor diameter of 1.0 cm or more, the positive rate for malignant lung cancer lesions (95.2%) was significantly higher (P < 0.001) than that for benign lung disease lesions (25.0%). These results thus indicate Tc-99m MIBI scintigraphy to be useful for qualitative diagnosis of lung peripheral coin lesions with a diameter of 1.0 cm or more.
研究了锝-99m 六甲基异丁基异腈（MIBI）闪烁扫描术用于定性诊断的情况。共检查了 31 例呼吸系统疾病患者的 37 个病灶（19 例原发性肺癌患者的 19 个病灶、3 例转移性肺癌患者的 8 个病灶以及良性肺部疾病患者的 10 个病灶）。原发性肺癌病灶的阳性率为 89.4%，转移性肺癌病灶的阳性率为 50.0%，良性肺部疾病病灶的阳性率为 20.0%。恶性肺癌的阳性率 77.7%显著高于良性肺癌（P < 0.01）。特别是对于肿瘤直径 1.0 cm 及以上的病灶，恶性肺癌病灶的阳性率（95.2%）显著高于良性肺部疾病病灶（25.0%）（P < 0.001）。因此，这些结果表明锝-99m MIBI 闪烁扫描术可用于定性诊断直径 1.0 cm 及以上的肺外周孤立性病灶。
