Spier R E
University of Surrey, Guildford, UK.
Folia Microbiol (Praha). 1997;42(2):105-12. doi: 10.1007/BF02898716.
The advantages and disadvantages of combination vaccines are set out with a clear indication that, although there are many (described and discussed) influences on in the immunogenicity of a vaccine it would still be of considerable value to be able to deliver such materials with the minimum number of needle-stick injections. Such a situation may become facilitated in the future as vaccines based on plasmid DNA become available; a prospect which is examined in outline in the final section.
文中阐述了联合疫苗的优缺点，并明确指出，尽管疫苗的免疫原性受到多种（已描述和讨论过的）因素影响，但能够以最少的注射次数接种此类疫苗仍具有相当大的价值。随着基于质粒DNA的疫苗问世，这种情况在未来可能会变得更加容易实现；最后一部分将简要探讨这一前景。
