α-肾上腺素能拮抗剂是有效的宫缩抑制剂吗？对产后大鼠的体内实验。

Are alpha-adrenergic antagonists potent tocolytics? In vivo experiments on postpartum rats.

作者信息

Zupkó I, Gáspár R, Kovács L, Falkay G

机构信息

Department of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.

出版信息

Life Sci. 1997;61(11):PL 159-63. doi: 10.1016/s0024-3205(97)00619-x.

DOI:10.1016/s0024-3205(97)00619-x

PMID:9307057

Abstract

The aim of this study was to investigate the effects of alpha-adrenergic antagonists on the motor activity of the postpartum uterus of the rat in vivo. Intrauterine pressure was assessed by means of a Millar catheter fitted with a latex microballoon. Some of the tested compounds (urapidil, yohimbine, phentolamine, benoxathian and prazosin) decreased the uterine activity to a significant extent (57.4-67.4%). However, none of the investigated alpha receptor blockers exerted the same effect as beta-adrenergic agonists. Our results suggest that alpha-adrenergic antagonists could possibly be used as an alternative to beta-adrenergic agonists in clinical tocolysis after an appropriate clinical evaluation.

摘要

本研究的目的是在体内研究α-肾上腺素能拮抗剂对大鼠产后子宫运动活性的影响。通过装有乳胶微球囊的Millar导管评估子宫内压力。一些受试化合物（乌拉地尔、育亨宾、酚妥拉明、贝诺沙嗪和哌唑嗪）可使子宫活性显著降低（57.4 - 67.4%）。然而，所研究的α受体阻滞剂均未产生与β-肾上腺素能激动剂相同的效果。我们的结果表明，经过适当的临床评估后，α-肾上腺素能拮抗剂在临床宫缩抑制中有可能用作β-肾上腺素能激动剂的替代品。