Graham A J, Finley R J, Worsley D F, Dong S R, Clifton J C, Storseth C
Department of Surgery, University of British Columbia, Vancouver, Canada.
Ann Thorac Surg. 1997 Sep;64(3):785-9. doi: 10.1016/s0003-4975(97)00628-0.
The purpose of this study was to determine the initial results of laparoscopic esophageal myotomy and anterior fundoplication in the treatment of 26 patients with achalasia.
Operative time, complications, and length of hospitalization were recorded for each patient. Postoperative outcomes were assessed by a standardized patient questionnaire, 24-hour esophageal pH studies, and esophageal transit studies.
Twenty-six consecutive patients with class IV dysphagia underwent a laparoscopic esophageal myotomy and anterior partial fundoplication, with a single incidence of intraoperative esophageal perforation. The mean operative time was 3.5 hours. The median length of hospitalization was 5 days. Of the 21 patients for whom follow-up was available (median follow-up, 4 months), 19 (90%) were satisfied and 2 (10%) were somewhat satisfied with their surgery. After operation, 14 of the 21 patients (67%) reported no dysphagia (class I), whereas 6 (28%) had class II dysphagia (less than once per week) and only 1 (5%) had class III dysphagia (greater than once per week). Liquid-phase esophageal transit studies (n = 14) revealed a significant improvement in esophageal clearance in the supine position from 18% before operation to 44% after operation (p = 0.006). Distal esophageal acid exposure was normal in 6 of 7 patients.
These early results suggest that laparoscopic esophageal myotomy and anterior partial fundoplication provides efficacious treatment of achalasia.
本研究的目的是确定腹腔镜食管肌层切开术和前位胃底折叠术治疗26例贲门失弛缓症患者的初步结果。
记录每位患者的手术时间、并发症和住院时间。通过标准化患者问卷、24小时食管pH值研究和食管通过时间研究评估术后结果。
26例连续的IV级吞咽困难患者接受了腹腔镜食管肌层切开术和前位部分胃底折叠术,术中食管穿孔发生率为1例。平均手术时间为3.5小时。中位住院时间为5天。在可获得随访的21例患者中(中位随访时间为4个月),19例(90%)对手术满意,2例(10%)对手术 somewhat satisfied。术后,21例患者中有14例(67%)报告无吞咽困难(I级),而6例(28%)有II级吞咽困难(每周少于1次),只有1例(5%)有III级吞咽困难(每周多于1次)。液相食管通过时间研究(n = 14)显示,仰卧位食管清除率从术前的18%显著提高到术后的44%(p = 0.006)。7例患者中有6例远端食管酸暴露正常。
这些早期结果表明,腹腔镜食管肌层切开术和前位部分胃底折叠术可有效治疗贲门失弛缓症。