Kahn J
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA.
Geriatrics. 1997 Sep;52 Suppl 2:S30-2.
The discovery of genetic mutations that increase the risk of developing Alzheimer's disease (AD) brings new promise of predictive testing for the disease. But the quality of information yielded by genetic tests for AD and the implications of this information raise serious questions about the use of such tests. This article examines some of the ethical issues related to predictive genetic testing for AD by examining the interpretation and potential misuses of such data, as well as the factors affecting the development and use of such testing technology. Finally, it poses some recommendations for how genetic testing for AD and the information it yields should be used.
增加患阿尔茨海默病（AD）风险的基因突变的发现为该疾病的预测性检测带来了新的希望。但AD基因检测所产生信息的质量以及该信息的影响引发了有关此类检测使用的严重问题。本文通过审视此类数据的解读和潜在滥用情况，以及影响此类检测技术开发和使用的因素，探讨了与AD预测性基因检测相关的一些伦理问题。最后，文章就AD基因检测及其所产生的信息应如何使用提出了一些建议。
