U1 小核核糖核蛋白复合体：结缔组织病中的自身抗原。最新进展。
The U1 snRNP complex: an autoantigen in connective tissue diseases. An update.
作者信息
Klein Gunnewiek J M, van de Putte L B, van Venrooij W J
机构信息
Department of Biochemistry, University Hospital Nijmegen, The Netherlands.
出版信息
Clin Exp Rheumatol. 1997 Sep-Oct;15(5):549-60.
PMID:9307865
Abstract
The U1 small nuclear ribonucleoprotein (snRNP) particle consists of an RNA backbone and eleven associated proteins. Both the RNA and some of the proteins are immunogenic in patients suffering from systemic lupus erythematosus or mixed connective tissue disease. An overview is given of the U1 snRNP particle with respect to its structure and function as well as its autoantigenicity.
摘要
U1小核核糖核蛋白（snRNP）颗粒由一条RNA主干和11种相关蛋白组成。在患有系统性红斑狼疮或混合性结缔组织病的患者中，RNA和部分蛋白都具有免疫原性。本文概述了U1 snRNP颗粒的结构、功能及其自身抗原性。
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