Bennie R E, Boehringer L A, McMahon S, Allen H, Dierdorf S F
Department of Anesthesia, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46202-5200, USA.
Paediatr Anaesth. 1997;7(5):399-403. doi: 10.1046/j.1460-9592.1997.d01-115.x.
Previous studies have shown over 70% of children require analgesics following bilateral myringotomy and tube placement (BM&T). This double-blind, placebo-controlled study compared the postoperative analgesic effects of preoperatively administered oral acetaminophen or ibuprofen. Forty three ASA I or II children age six months or older scheduled for elective BM&T were randomized to receive acetaminophen (paracetamol) 15 mg.kg-1, ibuprofen 10 mg.kg-1, or placebo. Postoperative pain was assessed using the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) upon arrival to the PACU and at 5, 10, 15, 30, 45, and 60 min. CHEOP scores did not differ between the groups at any time. There was no difference in the number of children receiving rescue analgesia. This study showed no benefit of preoperatively administered oral ibuprofen 10 mg.kg-1 or acetaminophen 15 mg.kg-1 over placebo for the relief of postoperative pain in children undergoing BM&T.
先前的研究表明，超过70%的儿童在双侧鼓膜切开置管术（BM&T）后需要使用镇痛药。这项双盲、安慰剂对照研究比较了术前口服对乙酰氨基酚或布洛芬的术后镇痛效果。43例计划进行择期BM&T的6个月及以上ASA I或II级儿童被随机分为三组，分别接受15mg·kg-1的对乙酰氨基酚（扑热息痛）、10mg·kg-1的布洛芬或安慰剂。患儿到达麻醉后恢复室（PACU）时以及术后5、10、15、30、45和60分钟，使用东安大略儿童医院疼痛量表（CHEOPS）评估术后疼痛情况。各时间点组间CHEOPS评分无差异。接受补救性镇痛的儿童数量也无差异。该研究表明，对于接受BM&T的儿童，术前口服10mg·kg-1布洛芬或15mg·kg-1对乙酰氨基酚在缓解术后疼痛方面并不优于安慰剂。
