Trüeb R M, Pericin M, Winzeler B, Wüthrich B, Burg G
Department of Dermatology, University Hospital of Zurich, Switzerland.
J Am Acad Dermatol. 1997 Sep;37(3 Pt 1):385-91. doi: 10.1016/s0190-9622(97)70136-1.
Eosinophilic myositis/perimyositis (EM/P) are a group of rare idiopathic muscle disorders associated with eosinophilia.
We describe the frequency and spectrum of cutaneous manifestations in EM/P and compare them with the idiopathic hypereosinophilic syndrome (HES).
We review the literature on EM/P and describe an additional case associated with angioedema.
Of a total of 26 reported patients with EM/P, cutaneous manifestations were observed in 10. These were, in order of frequency, deep subcutaneous induration, erythema, angioedema, urticaria, and papular lesions.
Skin lesions occur less frequently in EM/P than in HES. Although erythematous papulonodular lesions and urticaria/angioedema are most commonly observed in HES, the most frequent skin manifestations of EM/P are subcutaneous induration and erythema. In HES, angioedema has been correlated with a favorable prognosis. At least some of these patients apparently have an idiopathic eosinophilic disorder distinct from HES, including EM/P. In contrast to HES, the overall prognosis of EM/P is good, particularly when muscle lesions are focal, and the principal histopathologic finding is perimysial infiltrates.
嗜酸性粒细胞性肌炎/多发性肌炎（EM/P）是一组与嗜酸性粒细胞增多相关的罕见特发性肌肉疾病。
我们描述了EM/P皮肤表现的发生率和范围，并将其与特发性高嗜酸性粒细胞综合征（HES）进行比较。
我们回顾了关于EM/P的文献，并描述了1例与血管性水肿相关的病例。
在总共26例报告的EM/P患者中，10例观察到皮肤表现。按发生频率依次为深部皮下硬结、红斑、血管性水肿、荨麻疹和丘疹性病变。
EM/P中皮肤病变的发生率低于HES。虽然在HES中最常观察到红斑丘疹结节性病变和荨麻疹/血管性水肿，但EM/P最常见的皮肤表现是皮下硬结和红斑。在HES中，血管性水肿与预后良好相关。这些患者中至少有一些显然患有与HES不同的特发性嗜酸性粒细胞疾病，包括EM/P。与HES不同，EM/P的总体预后良好，尤其是当肌肉病变为局灶性时，主要组织病理学发现是肌束膜浸润。
