Hamai Y, Fujii T, Nishina H, Kozuma S, Yoshikawa H, Taketani Y
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
Hum Reprod. 1997 Aug;12(8):1816-8. doi: 10.1093/humrep/12.8.1816.
We present six cases of diabetes insipidus (DI) complicating pregnancy. In three cases, DI was manifested during pregnancy and required the administration of desmopressin acetate (1-desamino-8-D-arginine vasopressin, DDAVP). All these cases exhibited abnormal laboratory data such as an elevation of liver enzymes or a decrease in serum antithrombin III. The remaining three cases had suffered from DI before pregnancy which was well controlled on DDAVP. The clinical courses of these pregnancies were all uneventful subsequent to therapy. If DI is first recognized during pregnancy, attention should be paid to the possibility of abnormal liver function and eclampsia.
我们报告了6例妊娠合并尿崩症（DI）的病例。其中3例在孕期出现尿崩症，需要使用醋酸去氨加压素（1-去氨基-8-D-精氨酸加压素，DDAVP）进行治疗。所有这些病例均出现了实验室检查数据异常，如肝酶升高或血清抗凝血酶III降低。其余3例在妊娠前就患有尿崩症，使用DDAVP治疗后病情得到良好控制。这些妊娠在治疗后的临床过程均顺利。如果尿崩症在孕期首次被发现，应注意肝功能异常和子痫的可能性。
