Graham T B, Lovell D J
Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Curr Opin Rheumatol. 1997 Sep;9(5):434-9. doi: 10.1097/00002281-199709000-00010.
Outcome assessment has been a focus of recent research in rheumatic diseases and in pediatric rheumatology. The establishment of a preliminary core set of outcome variables for juvenile rheumatoid arthritis patients and a preliminary definition of improvement using these variables have been important steps toward standardization of outcome assessment. A population-based epidemiologic study has added to our knowledge of long-term outcome in juvenile arthritis and confirms the chronicity of disease that was found in previous studies. Standardization of outcome assessment in pediatric systemic lupus erythematosus has not been achieved to the same extent as in juvenile rheumatoid arthritis, but renal survival and overall mortality are important outcomes in this disease that are easily quantified. Recent studies of pediatric systemic lupus erythematosus demonstrate similarities with respect to organ involvement and overall survival between adult and pediatric lupus patients.
结局评估一直是近期风湿病及儿童风湿病研究的重点。为青少年类风湿关节炎患者建立一套初步的核心结局变量集以及使用这些变量对改善情况进行初步定义，是迈向结局评估标准化的重要步骤。一项基于人群的流行病学研究增加了我们对青少年关节炎长期结局的了解，并证实了先前研究中发现的疾病慢性特征。儿童系统性红斑狼疮结局评估的标准化程度尚未达到青少年类风湿关节炎那样的水平，但肾脏存活率和总体死亡率是该疾病易于量化的重要结局。近期关于儿童系统性红斑狼疮的研究表明，成人和儿童狼疮患者在器官受累情况和总体存活率方面存在相似之处。
