Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Università degli Studi di Genova, Genoa, Italy.
Curr Rheumatol Rep. 2021 Mar 8;23(4):23. doi: 10.1007/s11926-021-00988-x.
Providing a summary of the latest research on outcome measures in juvenile idiopathic arthritis, childhood -onset systemic lupus erythematosus, and juvenile dermatomyositis.
A rational management of patients with pediatric rheumatic diseases requires the regular assessment of the level of disease activity and damage, as well as the evaluation of therapeutic response through validated and standardized outcome measures. Ideally, such tools should be simple, feasible, and easily applicable in routine care. Recently, there has been a great deal of effort to refine existing tools and devise novel outcome measures, aiming to address the various aspects of disease impact and to improve the reliability of research studies and clinical trials. The newest outcome tools in pediatric rheumatology have markedly enlarged the spectrum of health domains assessable in a standardized way, thus increasing the reliability of evaluation of clinical response and fostering future clinical trials.
总结幼年特发性关节炎、儿童发病的系统性红斑狼疮和青少年皮肌炎的最新结局指标研究。
儿童风湿性疾病患者的合理治疗需要定期评估疾病活动度和损害程度，以及通过经过验证和标准化的结局指标评估治疗反应。理想情况下，这些工具应该简单、可行，并且可以在常规护理中轻松应用。最近，人们付出了大量努力来改进现有工具并设计新的结局指标，旨在解决疾病影响的各个方面，并提高研究和临床试验的可靠性。儿科风湿病学中最新的结局工具显著扩大了可标准化评估的健康领域范围，从而提高了临床反应评估的可靠性，并促进了未来的临床试验。
