Woo J I, Kim J H, Lee J H
Department of Psychiatry, Seoul National University College of Medicine, Korea.
Int Psychogeriatr. 1997 Jun;9(2):183-96. doi: 10.1017/s104161029700433x.
Using magnetic resonance imaging-based planimetry, we measured cortical and cerebral (cortical and ventricular) atrophy in 26 patients with Alzheimer's disease (AD) (age, 72.2 +/- 7.0) according to NINCDS-ADRDA criteria and 22 control subjects (age, 71.5 +/- 5.4). AD patients exhibited greater cerebral atrophy (p < .05) than control subjects. Cerebral atrophy was significantly correlated with age (r = .72, p < .0005) in healthy volunteers but not in AD patients. In AD patients, age of onset was negatively correlated with the estimated rate of disease-attributed cerebral degeneration ([observed atrophy--atrophy in normal aging calculated from the regression equation derived from the control group]/[duration of illness]) (r = -.54, p < .005). Multiple regression with interaction analysis demonstrated that age, age of onset, and their interaction successfully explained cerebral (R2 = .51, p < .05) and cortical (R2 = .64, p < .05) atrophy in patients with probable AD. Age of onset may be a strong predictor of the rate of cerebral degeneration in AD, and our results suggest that controlling age and the age of onset is essential in the quantitative study of AD.
我们采用基于磁共振成像的平面测量法，根据美国国立神经疾病和中风研究所-阿尔茨海默病及相关疾病协会（NINCDS-ADRDA）标准，对26例阿尔茨海默病（AD）患者（年龄72.2±7.0岁）和22名对照者（年龄71.5±5.4岁）的皮质和脑萎缩（皮质和脑室）情况进行了测量。AD患者的脑萎缩程度高于对照者（p<0.05）。在健康志愿者中，脑萎缩与年龄显著相关（r = 0.72，p<0.0005），而在AD患者中则无此相关性。在AD患者中，发病年龄与疾病归因的脑变性估计速率呈负相关（[观察到的萎缩 - 根据对照组得出的回归方程计算出的正常衰老萎缩]/[病程]）（r = -0.54，p<0.005）。多重回归及交互作用分析表明，年龄、发病年龄及其交互作用成功解释了可能患有AD的患者的脑萎缩（R2 = 0.51，p<0.05）和皮质萎缩（R2 = 0.64，p<0.05）。发病年龄可能是AD脑变性速率的一个强有力的预测指标，我们的结果表明，在AD的定量研究中，控制年龄和发病年龄至关重要。
