Hutchinson K M, McGill D J
Miami University of Ohio, Oxford, Ohio 45056, USA.
Scand Audiol. 1997;26(3):177-85. doi: 10.3109/01050399709074991.
Auditory event-related responses have been successfully used to differentiate the effects of auditory deprivation in laboratory animals and could provide an alternative and less subjective method of testing auditory deprivation. The purpose of this study was to investigate the efficacy of using the P300 response to measure auditory deprivation in monaurally aided children with hearing impairment. Seventeen children (8 female, 9 male) aged 9 to 18 years (M = 13.1 years) participated in the study. Ten subjects with bilateral congenital severe to profound sensorineural hearing losses (M = 87 dB) were recruited from a residential school for the deaf. All had worn monaural amplification for at least 8 years. Seven children with normal hearing sensitivity were matched for age effects. A two-tone auditory oddball paradigm was utilized to elicit the P300 responses. Statistical analysis revealed that the P300 amplitude was significantly greater in the aided ear compared to the unaided ear of the hearing-impaired group (p < 0.05). Two unaided ears of this group had no measurable responses. No other significant latency or amplitude differences were found within or between groups. Results of this investigation serve to reconfirm that binaural amplification should routinely be recommended for hearing-impaired children.
听觉事件相关反应已成功用于区分实验动物听觉剥夺的影响，并可为测试听觉剥夺提供一种替代性的、主观性较低的方法。本研究的目的是调查使用P300反应来测量单侧助听的听力受损儿童听觉剥夺情况的有效性。17名年龄在9至18岁（平均年龄13.1岁）的儿童（8名女性，9名男性）参与了这项研究。从一所聋人寄宿学校招募了10名双侧先天性重度至极重度感音神经性听力损失（平均损失87分贝）的受试者。所有人都佩戴单侧助听器至少8年。7名听力正常的儿童根据年龄进行匹配。采用双音听觉oddball范式来诱发P300反应。统计分析显示，听力受损组中，助听耳的P300波幅明显大于未助听耳（p<0.05）。该组的两只未助听耳没有可测量的反应。组内或组间未发现其他显著的潜伏期或波幅差异。本研究结果再次证实，应为听力受损儿童常规推荐双耳放大。
