Antal A, Kéri S, Bodis-Wollner I
Department of Physiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Neurosci Lett. 1997 Sep 5;232(3):179-81. doi: 10.1016/s0304-3940(97)00596-x.
The effects of sulpiride, a dopamine D2 receptor antagonist, were studied on visual event-related potentials in a monkey performing in a visual oddball task in order to investigate receptor specific mechanisms in visuo-cognitive processes. Following the injection of 0.35 mg/kg sulpiride i.m., the amplitude and latency of the primary (P100) and cognitive (P300) components did not change significantly. When 1.05 mg/kg sulpiride was administered, the latency of the primary and cognitive components increased. The amplitude of the P100 component decreased, while that of the P300 component increased. These data suggest that D2 receptors play an important role in visuo-cognitive processes in both physiological and pathological conditions such as Parkinson's disease and schizophrenia.
为了研究视觉认知过程中的受体特异性机制，对一只在视觉Oddball任务中执行的猴子，研究了多巴胺D2受体拮抗剂舒必利对视事件相关电位的影响。肌肉注射0.35mg/kg舒必利后，初级成分（P100）和认知成分（P300）的振幅和潜伏期没有明显变化。当给予1.05mg/kg舒必利时，初级成分和认知成分的潜伏期增加。P100成分的振幅降低，而P300成分的振幅增加。这些数据表明，D2受体在生理和病理条件下（如帕金森病和精神分裂症）的视觉认知过程中起重要作用。
