Takeshita S, Ogura C
Department of Neuropsychiatry, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Int J Psychophysiol. 1994 Feb;16(1):99-106. doi: 10.1016/0167-8760(94)90046-9.
Effects of the dopamine antagonist sulpiride on event-related potentials (ERPs) were investigated during an auditory odd ball task in 18 healthy volunteers. Sulpiride (150 or 300 mg) or an inactive placebo was administered according to a completely randomized double-blind cross-over design. ERPs were recorded 1 h after medication was given. Sulpiride shortened the P200 latency for frequent stimuli, but tended to increase the N200 and P300 latencies for rare stimuli. Although on the whole sulpiride had no effect on the amplitudes of the ERP components in the subjects, it increased the P300 amplitudes in the low P300 amplitude subjects and decreased them in the high P300 amplitude subjects. This tendency for a bidirectional response was also found for the N100 and N200 amplitudes. A single administration of 150 or 300 mg sulpiride is considered to affect the ERP latencies and amplitudes in healthy subjects, the bidirectional response that takes place being dependent on the difference in the initial values. The results of this study are discussed in relation to the 'Law of initial value'.
在一项听觉odd球任务中，研究了多巴胺拮抗剂舒必利对18名健康志愿者事件相关电位（ERP）的影响。根据完全随机双盲交叉设计给予舒必利（150或300毫克）或无活性安慰剂。给药1小时后记录ERP。舒必利缩短了频繁刺激的P200潜伏期，但倾向于增加罕见刺激的N200和P300潜伏期。虽然总体上舒必利对受试者ERP成分的波幅没有影响，但它增加了P300波幅低的受试者的P300波幅，并降低了P300波幅高的受试者的P300波幅。在N100和N200波幅方面也发现了这种双向反应的趋势。单次给予150或300毫克舒必利被认为会影响健康受试者的ERP潜伏期和波幅，所发生的双向反应取决于初始值的差异。本研究结果结合“初始值定律”进行了讨论。
