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[烫伤创伤时大鼠血液红细胞的电泳迁移率和氧化状态]

[Electrophoretic mobility and oxidizing status of rat blood erythrocytes at scald trauma].

作者信息

Matiushichev V B, Shamratova V G, Akhunova A R, Gerchikov A Ia

出版信息

Tsitologiia. 1997;39(2-3):177-80.

PMID:9312908
Abstract

On model of scald trauma the correlation of electrophoretic mobility of rat blood erythrocytes with intensity of lipid oxidation of erythrocyte membranes and with activity of catalase were studied. It is shown that in dynamics of scald disease development the erythrocyte mobility decreases, the velocity of oxidizing ability of their lipids increases and the protective action of blood antioxidation system is blocked. It is found that there is a close dependence between the level of oxidative processes and electrogenic properties of erythrocytes at the height of manifestation of scald toxaemia. A conclusion was made that the oppressing influence of increasing lipid oxidizing ability a on electrokinetic potential of erythrocytes is of a threshold nature and is realized through change in the membranes' state of these cells.

摘要

在烫伤创伤模型上,研究了大鼠血液红细胞的电泳迁移率与红细胞膜脂质氧化强度以及过氧化氢酶活性之间的相关性。结果表明,在烫伤疾病发展过程中,红细胞迁移率降低,其脂质氧化能力的速度增加,血液抗氧化系统的保护作用被阻断。发现在烫伤毒血症表现高峰期,氧化过程水平与红细胞的电特性之间存在密切关系。得出的结论是,脂质氧化能力增加对红细胞电动电位的抑制作用具有阈值性质,并通过这些细胞的膜状态变化来实现。

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