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[动物实验中严重烧伤时红细胞膜及红细胞结构若干特性的变化]

[Changes in several characteristics of the erythrocyte membrane and erythrocyte structure in severe burns in animal experiments].

作者信息

Zaets T L, Lavrov V A, Marchuk A I, Nosova I M

出版信息

Biull Eksp Biol Med. 1990 Jan;109(1):27-30.

PMID:2334790
Abstract

It is determined in experiments on rats that the IIIB degree thermal injuries of 20% of the total body surface significantly reduce the erythrocytic membrane's resistance and cause the production of peroxides in 15 minutes after trauma. Simultaneously the electrical properties begin to change. The structure of erythrocytes is also altered. In 30 minutes post injury these alterations are in progress, but in 60 minutes they are less expressed. The structure of the erythrocytes is significantly altered. The authors consider that the influence of membranotoxic factors--the products of free radicals' reactions and phospholipases--is accounted for all noticed alterations.

摘要

通过对大鼠的实验确定,全身表面积20%的ⅢB度热损伤会显著降低红细胞膜的抵抗力,并在创伤后15分钟导致过氧化物的产生。同时,电特性开始改变。红细胞的结构也发生改变。伤后30分钟这些改变仍在进展,但60分钟时则表现得较轻。红细胞的结构发生了显著改变。作者认为,膜毒性因子——自由基反应产物和磷脂酶的影响是所有观察到的改变的原因。

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