Christensen J H, Gustenhoff P, Korup E, Aarøe J, Toft E, Møller J M, Rasmussen K, Dyerberg J, Schmidt E B
Aalborg Sygehus, medicinsk endokrinologisk afdeling.
Ugeskr Laeger. 1997 Sep 8;159(37):5525-9.
There is evidence for an antiarrhythmic effect of n-3 polyunsaturated fatty acids (n-3 PUFA) in animals. The aim of the present study was to investigate the effect of dietary n-3 PUFA on ventricular arrhythmias and heart rate variability (HRV) in patients with a previous myocardial infarction. Fifty-five patients were randomized to receive either 5.2 g of n-3 PUFA daily for 12 weeks or placebo in a double blind, placebo-controlled study. Prior to randomization a 24-hour Holter recording was obtained, and this was repeated at the end of the study. The major end-points were the number of ventricular extrasystoles (VE)/24 hours and the 24-hour HRV. A non-significant decrease in VE/24 hours was found in both the n-3 PUFA group and among controls after dietary supplementation, whereas HRV significantly increased after n-3 PUFA compared to both baseline values (p = 0.04) and to controls (p = 0.01). The present study therefore supports the hypothesis that n-3 PUFA may have an anti-arrhythmic effect in humans.
有证据表明，n-3多不饱和脂肪酸（n-3 PUFA）在动物中具有抗心律失常作用。本研究的目的是调查饮食中n-3 PUFA对既往有心肌梗死患者室性心律失常和心率变异性（HRV）的影响。在一项双盲、安慰剂对照研究中，55例患者被随机分为两组，一组每天服用5.2 g n-3 PUFA，共12周，另一组服用安慰剂。在随机分组前进行一次24小时动态心电图记录，并在研究结束时重复进行。主要终点是室性期前收缩（VE）数量/24小时和24小时HRV。饮食补充后，n-3 PUFA组和对照组的VE/24小时均有非显著性下降，而与基线值相比（p = 0.04）以及与对照组相比（p = 0.01），n-3 PUFA组的HRV显著增加。因此，本研究支持n-3 PUFA可能对人类具有抗心律失常作用这一假说。
