Tingleff J, Munch M, Jakobsen T J, Torp-Pedersen C T, Olsen M E, Jensen K H, Jørgensen T, Kirchhoff M
Medicinsk afdeling C, Amtssygehuset i Glostrup, Befolkningsundersøgelsen i Glostrup.
Ugeskr Laeger. 1997 Sep 8;159(37):5529-33.
The aim of this investigation was to study the prevalence of left ventricular hypertrophy (LVH) in a hypertensive population with reference to a normotensive control group. From the general population, 3498 men and women aged 35, 45, 55 and 65 years old were invited to a health examination. Participants with blood pressure above 160 mmHg systolic and/or 95 mmHg diastolic or participants currently taking antihypertensive medication or having done so during the previous six months were asked to undergo an echocardiographic examination. Controls were randomly selected from the same population. Of 552 participants in the final study population, 194 were normotensive controls and 358 were in the hypertensive group. Echocardiographic measurements were made according to the "Penn" conventions and indexed for body surface. Cutoff values for LVH were 134 grams per m2 for males and 102 grams per m2 for women. Overall, we found that the prevalence of 1 VH was 14%/20% (men/women) in normotensives and 25%/26% in hypertensives (p < 0.01). By subdivision in age and sex groups we found that the relation between normotensives and hypertensives was significant in the age group of 65 years (p < 0.02 for males and p < 0.05 for females). The association between blood pressure and 1 VH in the general population is weak. 1 VH is only significantly more frequent among hypertensives as compared to normotensives in older people.
本研究的目的是参照血压正常的对照组,研究高血压人群中左心室肥厚(LVH)的患病率。从普通人群中,邀请了3498名年龄在35、45、55和65岁的男性和女性参加健康检查。收缩压高于160 mmHg和/或舒张压高于95 mmHg的参与者,或目前正在服用降压药或在过去六个月内服用过降压药的参与者被要求进行超声心动图检查。对照组从同一人群中随机选取。在最终研究人群的552名参与者中,194名是血压正常的对照组,358名属于高血压组。超声心动图测量按照“宾夕法尼亚”标准进行,并根据体表面积进行指数化。LVH的临界值男性为每平方米134克,女性为每平方米102克。总体而言,我们发现血压正常者中LVH的患病率为14%/20%(男性/女性),高血压患者中为25%/26%(p<0.01)。按年龄和性别分组细分后,我们发现65岁年龄组中血压正常者与高血压患者之间的关系具有显著性(男性p<0.02,女性p<0.05)。普通人群中血压与LVH之间的关联较弱。与老年人中的血压正常者相比,LVH仅在高血压患者中显著更常见。