Matiushin B N, Loginov A S, Tkachev V D
Vopr Med Khim. 1997 Jul-Aug;43(4):256-60.
Repression of cytochrom P-450-dependent hydroxylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione-dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases.
在慢性肝病患者的肝活检组织中证实了肝脏中细胞色素P - 450依赖性羟化和去甲基化受到抑制。与此同时，有人提出慢性肝脏病变患者中蛋白质 - 酶的氧化修饰引发了细胞色素P450系统的抑制。还发现了谷胱甘肽依赖性酶的激活。因此，作为慢性肝病解毒的补偿机制，揭示了结合作用和代谢过程的增强。
